CCRM Colorado is conducting a randomized control trial to examine the timing of trigger in an IVF cycle and its potential to impact patient outcomes. It is possible that if the duration of stimulation is too long and the trigger delayed that this could influence oocyte quality including aneuploidy rates. Our aim in the Test group is to initiate trigger when 1-2 18mm follicles are observed by ultrasound (the Control group will have trigger determined by primary MD). 100 patients will be computer randomized after the appearance of 1-2 18mm follicles. Endpoints will include oocyte yield, maturation, fertilization, embryo development, chromosome constitution and FET (frozen embryo transfer) outcomes.
- Planning to move forward with an IVF cycle
- Have met the requirements of being a patient at CCRM
- AMA: 39-44 years old
- DOR: AMH < 1 & FSH >10 (age independent)
- Contraindication for pregnancy
- Have not fulfilled requirements for IVF cycle
- Single gene couple or chromosomal rearrangement
- Severe male factor or testicular surgical sperm removal (need sufficient sperm for ICSI)
- One ovary
- Uterine anomalies
- Stage III or IV endometriosis
- Explained recurrent miscarriage
- PCO or PCOS
- Using donor oocyte or gestational carrier
Patients who qualify for the study, will receive the following complimentary; ultrasound during stimulation, one of the hormone drugs and comprehensive chromosome screening (CCS).
For more information on the Trigger Timing Study, call (303) 788-8300.