In Vitro Maturation Study2023-06-02T10:15:27-06:00

In Vitro Maturation Study

CCRM Fertility is seeking IVM study participants

Are you looking for an innovative fertility treatment with minimal burden and cost? CCRM Fertility is currently seeking participants for a new in vitro maturation (IVM) clinical research study.

What is IVM?

IVM requires significantly less hormonal stimulation than regular in vitro fertilization (IVF). Eggs from multiple small follicles are retrieved after just a few days of hormones. These eggs are retrieved in an immature state and are then matured in the IVF lab. Based on our published research, CCRM Fertility has developed a new maturation system that helps these eggs mature successfully. Once mature, IVF and embryo culture in the study proceeds identically to a typical IVF cycle.

Since IVM does not require aggressive stimulation of the ovaries with hormones, it dramatically reduces the number of injections the patients must receive, reduces the side effects often present with hormone treatment, and virtually eliminates the risk of ovarian hyperstimulation syndrome (OHSS).


To qualify for this study, participants must be:

  • 18-38 years old
  • Diagnosed with polycystic ovary syndrome (PCOS) or polycystic ovaries, or infertile women with good ovarian reserve
  • Have an antral follicle count (AFC) of 25 or greater
  • AMH > 3.5 ng/ml
  • Body Mass Index (BMI) <35 
  • Agree to have embryos biopsied for preimplantation genetic testing for aneuploidies (PGT-A)
  • Intend to perform embryo transfer within 4 months after completing the IVM cycle
  • Paternal (or donor) age <45, ejaculated sperm collection only (partner frozen and donor sperm acceptable), sperm morphology (strict criteria) >1%, motility > 20% and sperm count > 10 million per ml (so samples can be prepared through standard procedure)
  • Patients may not have had more than two failed IVF cycles in the past

All participants must undergo a full fertility work-up at CCRM Fertility in Lone Tree, Colorado to determine if they qualify for the study. If accepted into the study, treatment will take place at CCRM Fertility in Lone Tree, Colorado.

Most treatment costs associated with the study will be covered by CCRM Fertility, including a New Patient Consultation, fertility testing, IVM cycle, PGT-A, anesthesia, 1 frozen embryo transfer, and some medication. Additional frozen embryo transfers and some medications may not be covered.

Questions about the IVM study? Please call Rachel Makloski, Lead Researcher, at (303) 788-8300 ext. 1769 or email RachelM@colocrm.com.

Book your appointment Call