Dr. Krisher is a Reproductive Biologist focusing on oocyte and embryo physiology. She received her Bachelor’s degree in Biology from Hanover College, followed by a Master’s degree in Animal Sciences at North Carolina State University. She then worked for Granada Biosciences for several years before completing her PhD at Virginia Tech in Animal Science/Dairy. After graduate school, she worked for several years as an embryologist in human clinical reproduction, after which she returned to academia to complete a post-doctoral fellowship at the University of Wisconsin-Madison. She then joined the faculty of Purdue University, in the Department of Animal Sciences, before moving as Associate Professor to the Department of Animal Sciences at the University of Illinois, Urbana-Champaign.
As Research Director for CCRM, Dr. Krisher’s research program focuses on the physiology of oocytes and embryos, and specifically the involvement of metabolic processes in defining oocyte and embryo quality. Biochemical pathways within the embryo, influenced by the culture environment, have a dramatic impacts on long term viability post transfer. Using the mouse and bovine as a model for human embryos, Dr. Krisher’s laboratory is investigating the role of specific metabolic substrates at the molecular level on development, cell proliferation and differentiation. This research has resulted in data suggesting that there may be reliable metabolic markers that can predict implantation potential. In addition, Dr. Krisher’s research group is actively investigating loss of oocyte quality with advanced maternal age, and how this may be at least partially reversed by tailored metabolic support during in vitro embryo culture. Ongoing research in Dr. Krisher’s laboratory is focusing on in vitro oocyte maturation as an opportunity to manage specific metabolic disorders, resulting in improved oocyte and embryo competence. In her current role, she is translating these basic research findings into clinical application via improved culture media to advance human assisted reproduction.