Clinical Success Begins With the Lab
Many factors must come together to help our patients achieve a successful, healthy pregnancy. While the expertise of our world-class doctors and staff is an essential piece of the equation, a critical part of the in vitro fertilization (IVF) process happens in a place that most patients never see: the lab.
Not all IVF and comprehensive chromosomal screening (CCS) labs are equal in terms of the quality of the environment and measures taken to ensure the maximal chances of creating and growing embryos. It is the quality of our labs that sets us apart from our peers. Our expertise and dedication to lab operations continuously produces high quality CCS results enabling us to achieve some of the highest IVF with CCS live birth rates in the U.S. with close to 4,000 healthy babies born and counting.
Setting the Gold Standard for IVF Labs
CCRM’s IVF lab teams work to determine the best environment, technology and equipment to achieve successful pregnancies, and they engage in continuous monitoring and quality control to improve these standards.
Embryos are highly sensitive and to ensure that they’re not harmed during their time in the lab, all equipment used to handle or process cells are screened carefully for toxicity before being allowed in contact with eggs, sperm, or embryos.
Additionally, CCRM lab have dedicated HVAC units with specialized filtration to ensure the highest quality air. The laboratory also takes extreme measures to ensure stable temperature, pH and use of low oxygen for embryo culture. The environmental standards for CCRM labs exceed that of operating rooms. This rigorous approach helps us achieve the high pregnancy rates for which we are known.
Quality Across the CCRM Network
CCRM takes extraordinary measures to ensure consistency between all of our network facilities with respect to training of personnel, supplies and equipment and use of those materials. This starts with lab design and construction and continues with quality control and ongoing quality assessment on a daily, weekly, monthly and yearly basis to ensure success.
The CCRM network customized lab quality system is comprised of our proprietary protocols, highly-trained staff, quality controls, data analysis and focused execution. All of these components of the CCRM system contribute to the most accurate comprehensive chromosomal screening (CCS) results for infertility patients.
Highest Quality Results
CCRM sets and adheres to our own quality measures in the CCS lab that far exceeds the mandated regulatory standards. As a part of our stringent control measures, CCRM routinely performs a reanalysis on aneuploid embryos for confirmation of the original CCS biopsy result. The confirmation of aneuploidy in every reanalysis determines our clinical practice of only transferring euploid (chromosomally normal) embryos.
Chromosomal mosaicism is defined as the presence of two or more chromosomal cell lines in an individual embryo. A high incidence of chromosomal mosaicism can negatively impact the clinical benefit of aneuploidy screening as the biopsy would not represent the chromosomal constitution of the remaining embryo.
CCRM has reported the lowest chromosomal mosaicism rates in the U.S. at less than 3% of all biopsied blastocysts across the CCRM network. This closely resembles the incidence of chromosomal mosaicism in natural and IVF clinical pregnancies, and is a reflection of the quality of our IVF and CCS labs. The combination of optimized conditions, robust protocols and quality measures in both the IVF and CCS laboratories at CCRM contributes to the most successful clinical outcomes for our patients. CCRM is excited to present our data at the upcoming ASRM Annual Meeting in San Antonio in October 2017.